Table 5.
Treatment results of radiotherapy for pediatric craniopharyngioma
| Authors (year) | Number of patients | Follow-up | Radiotherapy | Additional treatment | Result | Late toxicity |
|---|---|---|---|---|---|---|
| Merchant et al., 200679) | 28 | 36.6 months (24.4–80.0) | Photon; 54.0–55.8 Gy, 1.8 Gy / Fr | Surgery (n = 27) | 3y-PFS 90.3% | - |
| Minniti et al., 200778) | 39 | 40 months (3–88) | Photon; 50 Gy / 30Fr, 50 Gy / 33Fr, 55 Gy / 33Fr | Surgery: Complete 2, Incomplete 34, Biopsy 3 | 3y-OS 100%, 5y-OS 100% 3y-PFS 97%, 5y-PFS 92% | No second tumors |
| Klimo et al., 201580) | 97 | 9 years (0.7–19.0) | Photon; 54 Gy / 30Fr | Surgery | 5y-OS 98.9%, 10y-OS 94.5% 5y-PFS 94.1%, 10y-PFS 87.8% | Vasculopathy: 1 |
| Luu et al., 200681) | 16 | 60.2 months | Proton; 50.4–59.4 GyE, 1.8 GyE / Fr | Surgery (all) RT (n = 1) | Local control 14/15 | Panhypopituitarism: 1 Vascular accident: 1 |
| Winkfield et al., 200982) | 24 | 40.5 months (6–78) | Proton; 52.2–54.0 GyE, 1.8 GyE / Fr | Surgery (all) 4 were biopsy | No local failure | - |
| Bishop et al., 201483) | 31 | 106 months | IMRT; 50.4–54.0 GyE, 1.8 GyE / Fr | Surgery: Gross total (n = 1) Subtotal (n = 11), Other (n = 19) | 3y-OS 96.8% 3y-NFFS 96.4% | Hypothalamic obesity: 9 |
| 21 | 33 months | Proton; 50.4–54.0 GyE, 1.8 GyE / Fr | Surgery: Gross total (n = 5) Subtotal (n = 9), Other (n = 7) | 3y-OS 94.1% 3y-NFFS 91.7% | Hypothalamic obesity: 4 |
Fr: fraction, y-NFFS: year nodular failure free survival, y-OS: year overall survival, y-PFS: year progression free survival.