TABLE 1 .
Average fractions of the metabolites taken up from the phagosome used for biomass synthesisa
| Metabolite | Uptake frequency in solutions | Mean biomass fraction |
|---|---|---|
| Cholesterol | 1.00 | 0.00 |
| Octadecanoate | 1.00 | 0.00 |
| Tetradecanoate | 1.00 | 0.07 |
| Hexadecanoate | 1.00 | 0.27 |
| Cytidine | 0.97 | 0.00 |
| Glucose | 0.97 | 0.11 |
| Leucine | 0.87 | 0.82 |
| Arginine | 0.87 | 0.89 |
| Glutamate | 0.80 | 0.62 |
| Pyruvate | 0.77 | 0.00 |
| Isoleucine | 0.77 | 0.37 |
| Aspartate | 0.73 | 0.03 |
| Ornithine | 0.70 | 0.00 |
| Serine | 0.63 | 0.08 |
| Methionine | 0.53 | 0.19 |
| Glycerol | 0.50 | 0.00 |
| Indole-3-acetaldehyde | 0.40 | 0.00 |
| Threonine | 0.40 | 1.00 |
| Citrate | 0.37 | 0.00 |
| Lysine | 0.37 | 0.06 |
| Phenylalanine | 0.33 | 0.54 |
| Valine | 0.30 | 0.73 |
| Histidine | 0.20 | 0.04 |
| Malate | 0.17 | 0.00 |
| Asparagine | 0.17 | 1.00 |
| Proline | 0.13 | 1.00 |
| Glycerol-3-phosphate | 0.10 | 0.00 |
| Succinate | 0.10 | 0.00 |
| Tryptophan | 0.10 | 0.02 |
| Glycine | 0.10 | 0.69 |
| Lactate | 0.07 | 0.00 |
| Alanine | 0.07 | 0.15 |
| Tyrosine | 0.03 | 0.00 |
a
Average fractions of the metabolites taken up from the phagosome used for biomass synthesis predicted by flux balance analysis with RNA-seq constraints. The fraction is an average of 36 model runs with different parameter sets constraining the lower bounds of mycobacterial and THP-1 biomass fluxes.