Table 1.

mEPC and eEPC properties in physiological calcium conditions

	mEPC				eEPC			QC
	Charge, pC	Rise time, ms	Decay τ, ms	Frequency, Hz	Charge, pC	Rise time, ms	Decay τ, ms
Control	−4.1 ± 0.1	0.33 ± 0.01	0.94 ± 0.04	1.5 ± 0.1	−261 ± 8	0.43 ± 0.01	1.24 ± 0.04	65 ± 6
R6/2	−3.4 ± 0.1*	0.37 ± 0.01*	1.16 ± 0.02*	0.9 ± 0.1*	−179 ± 7*	0.47 ± 0.01*	1.50 ± 0.04*	54 ± 5*
p value	1.4 × 10−4	3.34 × 10−5	8.36 × 10−4	1.9 × 10−4	2.00 × 10−6	2.11 × 10−4	2.6 × 10−4	0.022
t value	5.06	−5.83	4.16	−4.92	7.47	−4.85	4.75	−2.61
df	15	15	15	15	15	15	15	15

Summary of NMJ data from 81 R6/2 fibers (7 mice) and 87 control fibers (10 age-matched mice). The eEPC rise time was calculated from 10% to 90% of peak.

*Indicates a significant difference compared to control. A two-tailed t test was applied in all measurements.