Figure 1. Regenerating ulcers in ulcerative colitis (UC). a: Corrupted cystic crypts with asymmetric fission (vertical arrows), and horizontal fission (horizontal arrow) (H&E, ×4), b: Two hyperplastic, dilated crypts (left arrows) and one shoe-shaped crypt (central arrow). Note the absence of muscularis mucosa beyond the central arrow (H&E, magnification ×4), c: Crypts with asymmetric fission (upper crypt), one inverted T-shaped (left) and one L-shaped (right). (H&E, magnification ×10), d: Multi-lobate crypts with asymetric fission (H&E, magnification ×20), e: Crypt showing a central dilatation connected with five corrupted crypts, the one in the right ending in a three-foiled fission (H&E, magnification ×4), f: For comparison, colonic mucosa with chronic inflammation in UC without ulcerations showing no corrupted crypts (H&E, magnification ×4).