Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Aug 21;8:540. doi: 10.3389/fphar.2017.00540

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2017 Rahman, Abdul Murad, Mollah, Jamal and Harun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Pathways created by GeneMANIA connect the master regulator NFIX and its regulated genes IL6ST, TIMP1 and ITGB1. (A) 17 differentially expressed genes from microarray analyses showed connection with all regulated genes and NFIX. Some genes showed co-expression with NFIX, including PTCH1. (B) Successful construction of a new transcriptional network from both meta-analysis and microarray analyses. NFIX was identified as a master regulator that regulates the ITGB1, TIMP1 and IL6ST genes. Three new entities: the PTCH1, NFAT5 and GGCX, were also included in this metastasis regulatory network for lung cancer. NFIX is the master regulator; IL6ST, TIMP1 and ITGB1 are the NFIX-regulated genes and PTCH1, NFAT5 and GGCX are genes involved in the NFIX transcriptional regulatory network.