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. 2017 Aug 21;8:985. doi: 10.3389/fimmu.2017.00985

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Copyright © 2017 Rabbi, Eissa, Munyaka, Kermarrec, Elgazzar, Khafipour, Bernstein and Ghia.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of human catestatin (hCTS) treatment (1.5 mg/kg/day, i.r. 7 days) on weight loss and macroscopic score during colitis reactivation in quiescent colitic mice. The 7-day hCTS treatment did not improve weight loss observed in chronic quiescence colitic mice (A). However, during sacrifice hCTS treatment significantly improved stool consistency (B), rectal bleeding (C), and macroscopic score (D) in colitic mice. The macroscopic score was determined on the day of sacrifice considering fecal consistency, hyperplasia, and rectal bleeding. AU, arbitrary units, ^aP < 0.05 compared to the Control [No dextran sulfate sodium (DSS)/No hCTS] group; ^bP < 0.05 compared to the hCTS (No DSS) group; ^cP < 0.05 compared to the DSS (No hCTS) group; Bonferroni, one-way ANOVA. Control (n = 5), hCTS (n = 5), 4% DSS (n = 10), 4% DSS + hCTS (n = 12).