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. 2017 Aug 21;8:985. doi: 10.3389/fimmu.2017.00985

Figure 2.

Figure 2

Effect of human catestatin (hCTS) treatment (1.5 mg/kg/day, i.r. 7 days) on (A) representative colonic architecture and (B) composite histological score. When compared to the colonic appearance of non-colitic mice [no hCTS, (A):i and with hCTS, (A):ii], dextran sulfate sodium (DSS) treatment (A):iii resulted in massive infiltration of immune cells and damage of intestinal architecture. This cell infiltration was inhibited together with improvement of tissue architecture in hCTS-treated DSS mice (A):iv. Thus, the composite histological (microscopic) score was significantly improved in hCTS-treated colitic mice compared with vehicle-treated colitic mice (B). AU, arbitrary units; aP < 0.05 compared to the Control (No DSS/No hCTS) group; bP < 0.05 compared to the hCTS (No DSS) group; cP < 0.05 compared to the DSS (No hCTS) group; Bonferroni, one-way ANOVA. Control (n = 5), hCTS (n = 5), 4% DSS (n = 10), 4% DSS + hCTS (n = 12).