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. 2017 Aug 21;8:985. doi: 10.3389/fimmu.2017.00985

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Copyright © 2017 Rabbi, Eissa, Munyaka, Kermarrec, Elgazzar, Khafipour, Bernstein and Ghia.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Principal coordinate analysis based on the unweighted UniFrac distance metric. Fecal samples (A); Colonic mucosa-associated microbiota samples (B). Each color point represents an animal and color is shaded according to the treatment. The colitic induction clustered the microbial composition separately compared to non-colitic mice (β diversity, P-values <0.05). The human catestatin (hCTS) treatment (1.5 mg/kg/day, i.r. 7 days) did not change the microbial composition of colitic mice. P-values were calculated using permutational multivariate analysis of variance. Control (n = 2, fecal samples; n = 3, colonic mucosa-associated samples), hCTS (n = 5), 4% dextran sulfate sodium (DSS) (n = 10), 4% DSS + hCTS (n = 11, fecal samples; n = 12, colonic mucosa-associated samples).