Table 2.
Fold change of the pooled protein glycopatterns in sera from patients with CHB or CHC, and healthy volunteers (HV) based upon ratio of the NFIs of each lectin.
| Lectin | Specificity | Fold change(p value)a | ||
|---|---|---|---|---|
| CHB/HV | CHC/HV | CHC/CHB | ||
| HHL | High-Mannose, Manα1-3Man, Manα1-6Man, Man5-GlcNAc2-Asn | 5.01(<0.001) | – | 0.21(<0.001) |
| GSL-II | GlcNAc and agalactosylated tri/tetra antennary glycans | 2.35(0.04) | – | 0.24(0.008) |
| EEL | Galα1-3(Fucα1-2)Gal (blood group B antigen) | 3.33(0.001) | – | – |
| LTL | Fucα1-2Galβ1-4GlcNAc, Fucα1-3(Galβ1-4)GlcNAc, anti-H blood group specificity | 2.19(0.05) | 0.20(0.05) | 0.09(0.019) |
| MPL | Galβ1-3GalNAc, GalNAc | 4.99(<0.001) | – | 0.26 (0.003) |
| LEL | (GlcNAc)n, high mannose-type N-glycans | 5.62(0.034) | 5.02(0.058) | – |
| GSL-I | αGalNAc, αGal, anti-A and B | 24.59(<0.001) | – | 0.07(0.007) |
| DBA | αGalNAc, Tn antigen, GalNAcα1-3((Fucα1-2))Gal (blood group A antigen) | – | 0.47(0.004) | 0.26(<0.001) |
| LCA | α-D-Man, Fucα-1,6GlcNAc, α-D-Glc | 0.39(0.002) | – | 3.93(0.002) |
| PTL-II | Gal, blood group H, T-antigen | 9.67(<0.001) | – | 0.12(<0.001) |
| SBA | α- or β-linked terminal GalNAc, (GalNAc)n, GalNAcα1-3Gal, blood-group A | 16.58(<0.001) | 3.15(0.040) | 0.19(0.0012) |
| VVA | terminal GalNAc, GalNAcα-Ser/Thr(Tn), GalNAcα1-3Gal | 0.48(0.002) | – | – |
| NPA | Galβ1-3GalNAcα-Ser/Thr(T-antigen) | 3.97(<0.001) | – | 0.14(<0.001) |
| PSA | Fucoseα-1,6GlcNAc(core fucose) | 6.08(0.001) | – | 0.27(0.002) |
| ACA | α-D-Man, Fucα-1,6GlcNAc, α-D-Glc | 0.28(0.002) | – | 3.08(0.002) |
| WGA | Multivalent Sia and (GlcNAc)n | – | 2.32(0.013) | 2.00(0.05) |
| UEA-I | Fucoseα1-2Galβ1-4Glc(NAc) | 14.32(<0.001) | – | 0.11(0.02) |
| MAL-I | Galβ1-4GlcNAc, Siaα2-3Gal, Galβ1-3GlcNAc, Siaα2-3 | 3.39(0.001) | 2.97(0.005) | – |
| SNA | Sia2-6Galβ1-4Glc(NAc) | – | – | 2.26(<0.001) |
a
The NFIs of each lectin from CHB and CHC groups were compared with that from HV group based on their fold change (i.e., CHB/HV and CHC/HV).
—, no significant difference.