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. 2017 Aug 21;7:9018. doi: 10.1038/s41598-017-09432-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Surgical intervention to bridge the gap after chronic contusive SCI. (a) Schematic diagram illustrating the repair strategy. At two months post-injury, a cystic cavity forms at the injury site (pink oval, top drawing). For repair surgery, the cavity is exposed via the dorsal cord surface, scar tissue lining the cavity is gently removed, and several autologous peripheral nerve segments (green dotted lines, bottom drawing) are longitudinally placed in the cavity to span the lesion. aFGF+ChABC (orange) is injected rostrally, caudally, and at the sides of the spinal cord adjacent to the graft. A glue made of aFGF, ChABC, and fibrin is used to stabilize the graft (blue oval, bottom drawing). (b) GFAP-stained spinal cord two months post-contusion. Note the large cavity in the epicenter of the injured site, as indicated by*.