Table 2.
Multivariable analysis for disease-free survival by di chotomized autoantibodies to thyroid peroxidase (TPOAb)
| HR | 95% CI | p value | |
|---|---|---|---|
| TPOAb status | |||
| Negative (n = 1,568) | 1.00 | – | – |
| Positive (n = 406) | 1.00 | 0.81–1.24 | 0.98 |
| Nodal status | |||
| Positive (n = 1,567) | 1.00 | – | – |
| Negative (n = 407) | 0.49 | 0.37–0.64 | <0.001 |
| HER2 status | |||
| Negative (n = 1,323) | 1.00 | – | – |
| Positive (n = 408) | 1.19 | 0.97–1.46 | 0.09 |
| Unknown (n = 243) | 0.93 | 0.71–1.23 | 0.63 |
| Age group | |||
| <40 years (n = 306) | 1.00 | – | – |
| 40–49 years (n = 726) | 0.78 | 0.61–1.00 | 0.05 |
| 50–59 years (n = 757) | 0.75 | 0.59–0.96 | 0.02 |
| ≤60 years (n = 185) | 0.95 | 0.69–1.31 | 0.76 |
| Tumour grade | |||
| Grade 1 (n = 100) | 1.00 | – | – |
| Grade 2 (n = 758) | 1.15 | 0.74–1.78 | 0.55 |
| Grade 3 (n = 1,111) | 1.39 | 0.89–2.17 | 0.14 |
| Unknown (n = 5) | 0.77 | 0.10–5.75 | 0.80 |
| Tumour size1 | |||
| ≤2 cm (n = 725) | 1.00 | – | – |
| >2 and ≤5 cm (n = 1,077) | 1.37 | 1.12–1.66 | 0.002 |
| >5 cm (n = 171) | 1.88 | 1.41–2.52 | <0.001 |
| Type of surgery | |||
| Mastectomy (n = 1,079) | 1.00 | – | – |
| WLE (n = 895) | 0.79 | 0.66–0.95 | 0.01 |
HER2, human epidermal growth factor receptor-2; HR, hazard ratio (HR <1 indicates a favourable breast cancer outcome); WLE, wide local excision; 95% CI, 95% confidence interval.
1
The patient with unknown tumour size (n = 1) has not been considered for this analysis.