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. 2017 Aug 21;7:9022. doi: 10.1038/s41598-017-08422-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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ISL inhibits tumorigenesis and metastasis in MMTV-PyMT transgenic mice. (A) Representative images of solid tumors collected from vehicle group and ISL treatment group (50 mg/kg/d). (B) Representative micromorphology of the dissected tumors and lungs with HE staining in 100-fold magnification. (C) Scatter plots of individual tumors with mean weights at the end point of ISL treatment (n = 6). (D) Data about tumor burden of mice from vehicle and ISL-treated (n = 6). (E) Kaplan-Meier curve of mice survival in two different groups after ISL administration (n = 6). (F) IHC staining analysis of Bax and MMP-7 in vehicle tumor tissues and ISL-treated tumor tissues. Data represent the mean ± s.d. **P < 0.01.