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. 2017 Aug 21;7:8947. doi: 10.1038/s41598-017-04021-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(a) Cytotoxic effects of 1–4 on RBL-2H3 cells. (b) Inhibitory effects of 1–4 on the release of β-hexosaminidase in DNP-IgE-activated RBL-2H3 cells. (c) Inhibitory activity on lipid mediator LTB₄ secretion of 1–4 in RBL-2H3 cells. (d) Inhibition of IL-4 production of 1–4 in RBL-2H3 cells. Data are presented as the mean ± SD values of triplicate determinations. *P < 0.05, **P < 0.01, ***P < 0.001 versus DNP-BSA-treated group (n = 3). Data are analyzed by one-way ANOVA followed by Tukey’s Multiple Comparison Post-Test (GraphPad Prism 5.0).