Table 1.
1H (600 MHz) and 13C (150 MHz) NMR Data for Dysivillosins A–D (1–4) in Pyr-d 5.
| Position | 1 | 2 | 3 | 4 | ||||
|---|---|---|---|---|---|---|---|---|
| δ C | δ H (J in Hz) | δ C | δ H (J in Hz) | δ C | δ H (J in Hz) | δ C | δ H (J in Hz) | |
| 1α | 19.5, CH2 | 2.33, m | 22.8, CH2 | 2.35, m | 19.1, CH2 | 2.39, m | 22.5, CH2 | 2.41, m |
| 1β | 1.63, m | 1.55, dd (12.0, 2.4) | 1.57, m | 1.53, dd (12.0, 3.6) | ||||
| 2a | 26.3, CH2 | 2.38, m | 28.0, CH2 | 1.93, m | 26.1, CH2 | 2.23, m | 27.9, CH2 | 1.92, m |
| 2b | 2.14, m | 1.59, m | 2.07, m | 1.35, m | ||||
| 3α | 120.4, CH | 5.16, brs | 32.6, CH2 | 2.36, m | 120.4, CH | 4.98, brs | 32.5, CH2 | 2.26, td (15.0, 4.8) |
| 3β | 2.11, m | 1.96, m | ||||||
| 4 | 143.6, C | 159.4, C | 143.1, C | 159.0, C | ||||
| 5 | 38.0, C | 39.9, C | 37.8, C | 39.8, C | ||||
| 6α | 35.6, CH2 | 0.89, td (13.2, 3.6) | 36.4, CH2 | 1.29, dd (13.2, 3.6) | 35.5, CH2 | 0.75, td (13.2, 3.6) | 36.3, CH2 | 1.14, td (13.2, 3.6) |
| 6β | 1.49, dt (12.6, 3.0) | 1.45, m | 1.41, dt (12.6, 3.6) | 1.35, m | ||||
| 7α | 27.4, CH2 | 1.32, m | 27.4, CH2 | 1.42, m | 27.0, CH2 | 1.20, dd (13.2, 3.6) | 27.0, CH2 | 1.41, m |
| 7β | 1.37, td (12.6, 1.2) | 1.39, m | 1.30, td (13.2, 3.0) | 1.35, m | ||||
| 8 | 36.0, CH | 1.81, m | 36.3, CH | 1.76, m | 35.9, CH | 1.69, m | 36.2, CH | 1.63, m |
| 9 | 41.8, C | 42.2, C | 41.3, C | 41.6, C | ||||
| 10 | 45.9, CH | 1.55, d (12.0) | 48.2, CH | 1.36, dd (12.0, 2.4) | 45.9, CH | 1.39, dd (12.6, 1.2) | 48.3, CH | 1.20, dd (12.0, 1.8) |
| 11a | 17.6, CH3 | 1.45, br s | 102.6, CH2 | 4.46, s | 17.5, CH | 1.35, br s | 102.6, CH2 | 4.32, s |
| 11b | 4.38, s | 4.28, s | ||||||
| 12 | 19.6, CH3 | 1.03, s | 20.0, CH3 | 1.06, s | 19.5, CH3 | 0.96, s | 20.0, CH3 | 0.99, s |
| 13 | 17.3, CH3 | 1.20, d (6.6) | 17.4, CH3 | 1.20, d (6.6) | 16.6, CH3 | 1.09, d (6.6) | 16.8, CH3 | 1.10, d (6.6) |
| 14 | 17.4, CH3 | 0.94, s | 17.3, CH3 | 0.93, s | 17.3, CH3 | 0.87, s | 17.2, CH3 | 0.88, s |
| 15a | 37.8, CH2 | 3.13, s | 37.7, CH2 | 3.09, d (14.4) | 37.2, CH2 | 3.20, d (14.4) | 37.3, CH2 | 3.12, d (14.4) |
| 15b | 3.04, d (14.4) | 2.93, d (14.4) | 2.88, d (14.4) | |||||
| 16 | 128.4, C | 128.2, C | 124.1, C | 123.9, C | ||||
| 17 | 153.9, C | 153.8, C | 147.9, C | 149.7, C | ||||
| 18 | 106.1, CH | 7.74, s | 106.1, CH | 7.69, s | 122.3, C | 122.4, C | ||
| 19 | 120.8, C | 120.8, C | 105.0, CH | 7.68, d (2.4) | 105.1, CH | 7.63, d (3.0) | ||
| 20 | 147.8, C | 147.8, C | 154.3, C | 154.2, C | ||||
| 21 | 114.9, CH | 7.59, s | 114.6, CH | 7.53, s | 120.0, CH | 7.26, d (2.4) | 119.7, CH | 7.20, d (3.0) |
| 22 | 117.0, C | 117.0, C | 117.3, C | 117.2, C | ||||
| 23 | 129.1, CH | 8.13, dd (7.8, 1.8) | 129.1, CH | 8.10, dd (7.8, 1.8) | 129.5, CH | 8.21, dd (7.2, 1.8) | 129.4, CH | 8.18, dd (7.8, 1.8) |
| 24 | 118.4, CH | 7.17, dd (7.8, 4.8) | 118.4, CH | 7.16, dd (7.8, 4.8) | 118.6, CH | 7.21, dd (7.2, 4.8) | 118.5, CH | 7.16, dd (7.8, 4.8) |
| 25 | 145.4, CH | 8.46, dd (4.8, 1.8) | 145.4, CH | 8.45, dd (4.8, 1.8) | 145.8, CH | 8.52, dd (4.8, 1.8) | 145.8, CH | 8.50, dd (4.8, 1.8) |
| 27 | 163.5, C | 163.5, C | 163.3, C | 163.3, C | ||||
| 17-OH | 11.65, br s | 11.63, br s | 11.67, br s | 11.63, br s | ||||