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. 2017 Aug 21;7:8899. doi: 10.1038/s41598-017-09320-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Tissue enrichment for FTD-ALS based on the brain tissue specific DNA-methylation profiles of BrainSpan. (A) The hypergeometric test is used to compute P-value for each tissue based on the following parameters; total number of genes (M), number of tissue specific genes (K), number of significant differential methylated genes (N), and the overlap of significant differential methylated genes and the genes in the tissue specific gene set (x). The final P-value (P*) is corrected for multiple testing using Benjamini and Hochberg, and used for tissue selection with P_BH < 0.05. (B) Enriched tissues in FTD-ALS sorted in -log10(P_BH). (C) Genes are colored with the brain tissue specific color if overlap is seen with any of the significantly differential DNA-methylated genes in FTD-ALS.