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Comparison of the affinity of the BsAb (CD3×HER2) and it’s parental mAbs.
| Antibody | Ka (1/Ms) | Kd (1/s) | KD (nM) |
|---|---|---|---|
| CD3×HER2 BsAb (CD3) | 7.723E+4 | 1.202E-3 | 15.56 |
| Monovalent anti-CD3 mAb (CD3) | 1.455E+5 | 3.331E-3 | 22.81 |
| CD3×HER2 BsAb (HER2) | 4.894E+5 | 5.976E-5 | 0.1221 |
| Monovalent Trastuzumab (HER2) | 4.466E+5 | 9.046E-5 | 0.2026 |
