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. 2017 Aug 22;7:9157. doi: 10.1038/s41598-017-08837-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Model depicting the proposed role of SUN1 phosphorylation in mRNA export. SUN1 binds mRNP/NXF1 complexes at the nuclear envelope (NE). Upon an unidentified signal, SUN1 is phosphorylated at S113 by a PKC. This reduces the NXF1 affinity and the complex then binds to NUP153 which is also associated with SUN1 at the NE. The mRNP is targeted to the nuclear pore and exported.