Table 1.

In vivo pharmacokinetics of BHX in rats following intraperitoneal injection at doses of 50 and 100 μg/kg.

Parameter	BHX 50 μg/kg	BHX 100 μg/kg
AUC0-t (ng∙h/ml)	1773.76 ± 325.48	2300.01 ± 412.06
AUC0-t (ng∙h/ml)	1816.25 ± 286.71	2347.91 ± 302.59
MRT0-t (h)	6.80 ± 1.25	6.36 ± 1.32
t1/2 (h)	4.82 ± 0.93	4.11 ± 0.81
Tmax (h)	5.37 ± 1.16	5.62 ± 1.38
CL (L/h/kg)	0.028 ± 0.006	0.043 ± 0.007
Vd (L/kg)	0.192 ± 0.047	0.253 ± 0.062
Cmax (ng/ml)	325.15 ± 55.15	405.22 ± 87.52

Abbreviations: AUC, area under the concentration-time curve; MRT, mean residence time; t_1/2, half-life; T_max, time to maximum plasma concentration; CL, clearance; V_d, volume of distribution; C_max, maximum plasma concentration.