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. 2017 Aug 22;7:9030. doi: 10.1038/s41598-017-09702-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Pioglitazone enhanced cytosolic lipolysis, β-oxidation and autophagy but decreased lipogenesis. Mice were fed with chow diet, high fat diet, or high fat diet co-administered with pioglitazone (100 mg/kg/d) for 8 weeks. (A) Protein expressions related to cytosolic lipolysis (ATGL, HSL), β-oxidation (CPT-1A) and autophagy (mTOR, p-mTOR, Beclin-1, ATG7, LC3-I, LC3-II, and LAL) and the quantitative results. (B) Messenger RNA expressions of the above genes. (C) Protein expressions of the lipogenesis genes (FAS, ACC1) and the quantitative results. GAPDH served as a loading control. P < 0.05 indicated as significant, *vs chow diet, Δvs high fat diet.