Fig. 1.

Summary of BRCA locus-specific LOH status of breast and ovarian tumors from individuals with germline BRCA1 and BRCA2 mutations. 100 tumors with germline BRCA1 and BRCA2 mutations were identified in The Cancer Genome Atlas (TCGA) data set and 60 tumors underwent whole exome sequencing (WES) at the University of Pennsylvania (Penn). BRCA locus specific loss of heterozygosity (LOH) was determined as described. *One BRCA1 breast tumor in the TCGA had a somatic BRCA1 mutation at 21% allele frequency and one BRCA2 breast tumor in the TCGA had a somatic BRCA2 mutation at 35% allele frequency. These two tumors were removed from the totals for LOH negative tumors