Table 4.
Cis-regulatory transcription factor binding motifs that exist in promoter sequences of differentially expressed (DE) microRNAs and their positively correlated target genes.
| MicroRNA | Target gene | MicroRNA-target gene expression correlation (R2) | Common cis regulatory promoter motifs in microRNA and target gene |
|---|---|---|---|
| mir-92-5p | GSONMT00020058001: homeobox protein orthopedia b-like | 0.9 | HNF-3beta, AML1, TFIID, HNF-3 |
| mir-26a-5p | GSONMT00040924001: kelch repeat and btb domain-containing protein 11-like | 0.9 | AR, C/EBPbeta, c-Jun, Fli-1, IRF-2, NF-AT1, NF-AT2, NF-AT3, NF-muNR, POU1F1, PR B |
| let-7a-5p | GSONMT00042722001: inhibitor of growth protein 5-like | 0.8 | AP-3, AR, C/EBPbeta, CBF(2), CP2, GATA-1, HNF-3alpha, HNF-3beta, HOXA4, NF-Y, PR B, Smad3, SXR:RXR-alpha, TBP |
| mir-222-3p | GSONMT00046577001: synembryn-b-like isoform × 2 | 0.8 | C/EBPgamma, c-Jun, NF-Y, RAR-gamma, Smad3, WT1 I |
| mir-10c-5p | GSONMT00022788001: transcription elongation factor SPT6-like | 0.8 | HNF-3alpha, Elk-1, HNF-3beta |
| let-7c-5p | GSONMT00013587001: collectrin-like isoform | 0.8 | AR, Crx, HNF-3alpha, HNF-3beta, HOXD10, HOXD9, Pax-2.1, PR B, TFIID |
| mir-130-5p | GSONMT00036000001: uncharacterized protein | 0.8 | CP2, HNF-3alpha, HNF-3beta, PR B, RAR-gamma |
| mir-27b-5p | GSONMT00073742001: serine threonine-protein phosphatase 6 regulatory ankyrin repeat subunit c | 0.8 | AhR, AR, c-Myb, NFI/CTF, POU1F1b, POU1F1c, PR A, PR B |
| mir-29c-5p | GSONMT00037095001: protein NLRC3-like | 0.8 | AP-3, ENKTF-1, HNF-3beta, NF-Y, PPAR-alpha:RXR-alpha, PR B |
| mir-221-5p | GSONMT00080720001: lathosterol oxidase | 0.7 | AR, C/EBPbeta, c-Jun, HNF-3beta, p53, PEA3, PR B |
| mir-132-3p | GSONMT00033564001: dihydropyrimidinase | 0.7 | AP-3, CBF(2), CP2, Elk-1, ER-alpha, ER-beta, MyoD, NF-1, NF-Y, PU.1, SF-1, T3R-beta |
| mir-30d-5p | GSONMT00002523001: solute carrier family 12 member 9-like | 0.7 | AR, PR B, CP2 |
| mir-462-5p | GSONMT00075887001: ATP-dependent 6-phosphofructokinase, muscle type-like | 0.7 | HNF-3alpha, MyoD, NF-AT3, NF-AT2, PR B |
| mir-133a-3p | GSONMT00002111001: TPA_inf: tachykinin 4 | 0.7 | c-Fos, c-Jun, COE1, GATA-1, HNF-3, HNF-3beta, IRF-1, MAZ, NF-AT1, Pbx1b, PEA3, PR B |