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. 2017 Aug 21;7:9000. doi: 10.1038/s41598-017-09460-2

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison of the 107_A07 Fab with compact (InlB-bound) and extended (HGF/SFβ-bound) structures of the MET ectodomain. (A) The compact (blue) and extended (grey) conformations of extracellular MET (amino acids 25–741). The structure of compact MET is from PDB accession 2UZY (chain B), (complex of MET with InlB); the structure of MET in extended conformation is from PDB accession code 1SHY (HGF/SF beta chain in complex with SEMA domain of MET). (B) Superposition of the MET-107_A07 Fab complex (shown in green) with MET in compact conformation (2UZY), obtained by superposing the CR domains. The MET CRD-Ig1-Ig2 domains are oriented perpendicular to the image. The InternalinB structure is shown in red. (C) Superposition with MET in extended conformation (1SHY). The position of Ig1-Ig2 was obtained as described in (B). (D) Superposition with MET in extended conformation (4K3J, complex of MET and the Fab fragment of onartuzumab). The onartuzumab structure is shown in magenta.