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. 2017 Aug 22;7:9064. doi: 10.1038/s41598-017-09276-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Modeling structure analyses of RAX mutation. (A) Map of 7.05 kb RAX gene. Predicted RAX domain structure. Homeobox is indicated in light blue and low complexity region is indicated in dark blue. (B) Predicted crystal structure of the RAX wide type and mutant type including homeobox domain of RAX (residue136-198). A view of residue 38 highlighting the WT (isoleucine) and mutated (threonine) at the position is in the two bottom boxes.