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. 2017 Aug 22;7:9108. doi: 10.1038/s41598-017-09203-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The VIP-PLS-DA models, ROC curves obtained from the fusion of data from urine and serum samples. (A) – NN vs HC; (B) – FA vs HC; (C) – TC vs HC; (D) – TC vs NN; (E) – FA vs NN; (F) – FA vs TC; (G) – P vs HC. Red triangles – healthy controls; blue boxes – non-neoplastic nodules; yellow diamonds – follicular adenoma; black hexagons – papillary thyroid cancer; gold circles – patients. Solid symbols: training set; empty symbols: predicted test set. Small violet circles – metabolites that influence group differentiations in PLS-DA models.