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. 2017 Aug 22;7:9095. doi: 10.1038/s41598-017-09242-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Functional connectivity (Fc) maps for the left inferior frontal gyrus (IFG) seed (panel a) and right insula seed (panel b). Upper and middle row: Statistical maps resulting from the seed-based correlation analysis separate per group. Seeds are overlaid in green (left IFG seed) or dark blue (right insula seed). Maps are thresholded at q(FDR) < 0.05. Lower row: Group differences in functional connectivity per seed region (red indicates patients show increased connectivity as compared to controls, blue indicates patients show decreased connectivity as compared to controls).