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. 2017 Sep 20;27(9):534–549. doi: 10.1089/ars.2016.6706

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Copyright 2017, Mary Ann Liebert, Inc.

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FIG. 6. — Inhibition of the Trx system by AF causes pyramidal cells in CA3 to perform similarly to those in CA1. OxD profiles of CA1 (left) and CA3 (middle) during 10/20/30 min basal/OGD/RP are represented as mean ± SEM, n = 6 OHSCs. The steady OxD_S of each period is acquired from the time frame (5 min) indicated by the horizontal line shown in right. The profiles of mit-OxD_P and OxD_G, and cytosolic OxD_P and OxD_G are displayed from (A) to (D). Statistical significance of the effect of AF in CA1 (or CA3) is indicated above the OxD traces. Statistical significance of CA1/CA3 differences (with or without AF) is indicated above the bar graphs on the right. Inhibition of the Trx system by AF increases OxDs in both mitochondria and cytosol and removes the difference of mit-OxDs between CA1 and CA3. See Figure 1 legend for indicators of statistical significance. n.s. is not remarked.