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Anti-Leishmania activity of EtOH-Ext, Hex-F, and Lupeol from P. insignis stem bark, and cytotoxic effects against murine peritoneal macrophages.
| Compounds | Macrophages | Promastigotes | Axenic amastigotes | |
|---|---|---|---|---|
| CC50 (µg/mL) | CI50 (µg/mL) | CI50 (µg/mL) | SI | |
| EtOH-Ext | 341.95 | 174.24 | 40.58 | 8.42 |
| Hex-F | 71.65 | 45.23 | 35.87 | 1.99 |
| Lupeol | 144.00 | 39.06 | 44.10 | 3.26 |
| Amph B | 8.75 | 1.74 | 0.20 | 43.75 |
SI: Selectivity index for axenic amastigote forms of L. amazonensis (CC50/IC50).
