Table 1.

Melanoma cancer formulations summarized.

Polymer	Antineoplastic agents/action	Cancer	Route of administration	Reference
MPEG-b-(PCL-ran-PLLA) diblock copolymer (MCL)	5-Fluorouracil	Melanoma in vivo mice model tumor	Subcutaneously injected drug delivery system	Seo and coworkers [33]
Hydroxypropyl-β-cyclodextrin supported in in-situ-forming hydrogels with poloxamers 407 and 188	Curcumin/antioxidant, anti-inflammatory, antiproliferative and antiangiogenic activities	In vitro  melanoma model in cell lines	Transdermal drug delivery system	Sun and coworkers [34]
Pluronic F127	Ibuprofen/nonsteroidal anti-inflammatory	In vitro  melanoma model in cell lines	Topical/transdermal drug delivery system	Marques and MacNeil [35]
Hydrazone cross-linked sericin/dextran	Doxorubicin	In vivo melanoma model in male mice	Subcutaneously injected drug delivery system	Liu and coworkers [36]
Glycol chitosan benzaldehyde capped poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) (GC-OHC-PEO-PPO-PEO-CHO)	Paclitaxel and doxorubicin (combination therapy)	In vivo melanoma model in male mice	Subcutaneously injected drug delivery system	Zhao and coworkers [37]
Poly(2-hydroxypropyl acrylate/itaconic acid) (P(HPA/IA))	Ni(II) complex with oxaprozin/antiproliferative activity	In vitro melanoma cancer cell lines	Topical/transdermal drug delivery system	Babić and Coworkers [38]
Nanohydrogels (NHs) based on cholesterol-graft-hyaluronic acid	Bovine serum amine oxidase (BSAO)	In vitro melanoma cancer cell lines	Topical drug delivery system	Montanari and coworkers [39]
Arginate/chitosan	Bovine serum amine oxidase (BSAO)		Topical drug delivery system	Agostinelli and coworkers [40]
Pluronic F127	AuNPs and DOX	In vivo melanoma model in male mouse	Subcutaneously injected drug delivery system/hyperthermia therapy	Li and coworkers [41]