FIG. 7.

Synergistic beneficial effect of PBT2 and TETRA. (A, B) Pharyngeal performance of worms fed 100 μg/ml cardiotoxic LC (H7-BJ) for 2 h and then treated for 30 min with (A) 25 μM CQ, 20 μM TETRA, or 2 nM PBT2 or with (B) 0.5–2 nM PBT2 alone or together with 20 μM TETRA. Control worms fed vehicle alone. **p < 0.001, *p < 0.005 versus vehicle, °°p < 0.001 versus cardiotoxic LC, one-way ANOVA and Bonferroni's post hoc test. ^§§p < 0.01 significant interaction versus worms fed cardiotoxic LC +0.5 nM PBT2, two-way ANOVA and Bonferroni's post hoc test.