Table 1.

Doses of ketamine used to treat depression and those that have toxic effects in humans

Dose (mg/kg)	Outcome measures
Doses of ketamine that have antidepressant effects
0.5	21-item Hamilton Depression Rating Scale [6]
0.5	25-item Hamilton Depression Rating Scale [7]
0.5	Montgomery–Åsberg Depression Rating Scale [8, 9, 74, 75]
0.5	Response rate [34]
0.75	28-item Hamilton Depression Rating Scale [76]
1	Response rate [77]
0.2, 0.4	Montgomery–Åsberg Depression Rating Scale total score [71]

Dose	Toxic actions
Doses of ketamine that cause toxic effects
2 mg/kg	Worsening of cerebral atrophy [26]
1.42 g	Chronic impairment of episodic memory [27]
0.4 and 0.8 mg/kg	Impairment of learning and memory [36]
50 and 100 ng/mL	Impairment of episodic memory and recognition memory [37]
0.23 and 0.5 mg/kg	Impairment of executive function [45]
0.54 mg/kg	Mild increases in blood pressure [52]
0.23 mg/kg	Adverse events related to mental status [47]
0.5 mg/kg	Psychotomimetic effects [40, 78]
0.3 and 0.5 mg/kg	Cardiovascular side-effects [8, 49]
18.5 g/week	Uropathy [56]