Fig. 4.

Effects of resveratrol (Res) on the expression of Glu-6 and GABA_A receptor-α1 in different phases of epilepsy with Western blot analysis. A Representative western blots showing that Res modulated the expression of GluR6 in the hippocampus in the acute, silent, and chronic phases. B Densitometric analysis showing that GluR6 expression was reduced in the acute phase, barely detectable in the silent phase, and markedly increased in the chronic phase in the KA group. Resveratrol treatment up-regulated GluR6 expression in the acute and silent phases, but down-regulated it in the chronic phase. C Western blotting analysis of the effects of Res on the expression of GABAR-α1 in the hippocampus in the acute, silent, and chronic phases. D Densitometric analysis showing that GABA_AR-α1 expression was significantly reduced in the acute phase, barely detectable in the silent phase, and markedly increased in the chronic phase in the KA group. Res treatment up-regulated GABA_AR-α1 expression in the acute, silent, and chronic phases. *P <0.05, **P <0.01 vs control group; ^# P <0.05, ^## P <0.01 vs KA group (n = 8).