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. 2017 May 22;33(4):396–404. doi: 10.1007/s12264-017-0140-3

Fig. 2.

Fig. 2

Effects of NAAG on heroin self-administration under the FR1 schedule. A, B. Pretreatment with NAAG (50 and 100 μg/10 μL in each nostril) or NAAG (100 μg/10 μL in each nostril) plus LY341495 (1 mg/kg, i.p.) had no effects on the active pokes and heroin infusions on day 11, but significantly inhibited the active pokes and heroin infusions on day 12. The active pokes and heroin infusions in these groups recovered to normal levels on day 13. C, D. NAAG (100 μg/10 μL in each nostril) was administered on day 11 but LY341495 (1 mg/kg, i.p.) was injected 24 h after NAAG in this experiment. The active pokes and heroin infusions were significantly inhibited by NAAG but not with LY341495. The inhibitory effects on the active pokes and heroin infusions of NAAG were restored by the combined treatment with LY341495. (*P < 0.05, **P < 0.01 compared with control group; # P < 0.05 compared with NAAG group).