Fig. 2.

Network-based statistic (NBS) results. A In schizophrenic patients (SCH), 12 rich-club connections between 13 nodes were decreased (P < 0.05, NBS corrected) and 11 feeder connections between 13 nodes were disrupted (P < 0.05, NBS corrected). In unaffected parents (SCHP), the decreased feeder edges were specific to 7 edges connecting 9 nodes (P < 0.05, NBS corrected). B Disrupted rich-club and feeder edges exhibited better discriminative power with an accuracy of 92.7% in distinguishing SCHs from young healthy controls (HC1). For differentiating SCHPs from old healthy controls (HC2), the feeder edges identified by NBS improved the discriminative power with an accuracy of 84.4%.