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Suppression of SIRT1 reversed the effect of GA on LPS-induced inflammatory response and renal injury in vivo. The levels of IL-6 (a), TNF-α (b), BUN (c), Kim-1 (d), NF-κB activity (e) were measured in LPS, LPS + GA, and LPS + GA + EX-527 groups in vivo. f The protein levels of p-IκBα and IκBα in LPS, LPS + GA, and LPS + GA + EX-527 groups in vivo were determined by western blot. n = 10, *P < 0.05
