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. 2017 Aug 23;18(1):90. doi: 10.1186/s10194-017-0800-8

Table 2.

Headache incidences registered during randomized controlled trials (RCT) and open label clinical trials with pinacidil

Paper Study design Dose (daily) Indication No. of patients Headache No.
Muiesan et al. 1985, Eur. J. Clin. Pharmacol [86]. RCT 30–75 mg Essential hypertension 30 2 (7%)
Laher & Hickey 1985, J. Int. Med. Res [87]. Open label 12.5 mg Healthy volunteers 12 1 (8%)
D’Arcy et al. 1985, Eur. J. Clin. Pharmacol [88]. Open label 20–100 mg Essential hypertension 23 4 (17%)
Zachariah et al. 1986, Eur. J. Clin. Pharmacol [89]. RCT 62 mg (mean) Essential hypertension 23 ----
Sterndorff & Johansen 1988, Acta Med. Scand [90]. RCT 25–100 mg Essential hypertension 71 7 (10%)
Goldberg 1988, J. Cardiovasc. Pharmacol [91]. RCT 25–100 mg Essential hypertension 145 31 (21%)