Figure 1.

A schematic overview of simulations carried out in this work. (A) The interaction between α_IIbβ₃ and talin was modeled in a set of control simulations marked as α_IIbβ₃_C. (B) α-Actinin, talin, and α_IIbβ₃ were all included in the binding simulations (α_IIbβ₃_B). (C) α-actinin was absent in the α₅β₁ control simulations, marked as α₅β₁_C, whereas (D) it was included along with talin and α₅β₁ in the binding simulations. For clarity, the lipid membrane is not shown. To see this figure in color, go online.