FIG. 1.

Patient with a grade II oligodendroglioma. Top row shows tongue motor fMRI activation map (tbfMRI) (Z-score >4.0) overlaid on T1-weighted structural images. Second, third, and bottom rows show SCA, ALFF, and fALFF maps (SCA >1.0, ALFF >0.4 and fALFF >0.36) from rsfMRI. Blue contours display ROIs from automatically parcellated combined precentral and postcentral gyri. Notice in all maps that there is abnormally decreased signal in the IL perirolandic ROIs compared with the normal CL perirolandic ROIs. In the setting of preserved clinical motor function and excellent task performance, these findings are indicative of tumor-induced NVU. ALFF, amplitude of low-frequency fluctuations; CL, contralesional; fALFF, fractional ALFF; fMRI, functional magnetic resonance imaging; IL, ipsilesional; NVU, neurovascular uncoupling; ROI, region of interest; rsfMRI, resting-state fMRI; SCA, seed correlation analysis; tbfMRI, task-based functional MRI. Color images available online at www.liebertpub.com/brain