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Alteration of 68Ga-PSMA-HBED-CC uptake regarding the level of PSMA. (a) Levels of PSMA in three models of CRPC cell lines. (b) The uptake of 68Ga-PSMA-HBED-CC in different cell lines after 3 h incubation. (c) The alteration of 68Ga-PSMA-HBED-CC uptake in the low-PSMA-expressing model. (d) The schematics of the three CRPC models with different PSMA expression levels and their associated radioligand uptake. (Adapted and modified from Ref. [29])
