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Dual agonist occupancy of AT1R-α2cAR heterodimers activates different types of G-proteins from a single agonist occupancy of each protomer. (A) Binding of Ang II to the AT1R protomer (light blue) causes Gq activation. (B) Binding of NE to α2cAR (orange) causes Gi activation. (C) Simultaneous binding of Ang II and NE to AT1R-α2cAR heterodimers causes Gs activation.
