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. Author manuscript; available in PMC: 2017 Aug 23.
Published in final edited form as: J Invest Dermatol. 2016 Aug;136(8):1538–1540. doi: 10.1016/j.jid.2016.04.026

Figure 1. Polycomb group complexes in mammalian skin.

Figure 1

PcG proteins form two major complexes, PRC1 (a) and PRC2 (b). Both complexes contain core subunits that interact with other accessory proteins and define the complete composition of each subcomplex. The accessory proteins regulate recruitment to specific chromatin domains and/or modulate the catalytic activity of the core complex. (a) Association of PRC1 core subunits Ring1a/b and Pcgf2/4 with one of Phc and Cbx proteins defines the canonical PRC1 complex, while a complex with Rybp/YAF and/or Kdm2b forms the non-canonical PRC1. (b) Three core subunits of PRC2 can associate with different proteins at the same time.