Figure 2. tENTH is a multimer in crystals but a monomer in solution.
(A) Top panel: The tENTH 1–136 construct crystallized as a dimer (labeled A and B) in the asymmetric unit. Bottom panel: The tetramer observed in the crystal lattice of the tENTH 1–153 structure. (B) Gel filtration profile of the tENTH domain (blue trace) with standards (grey trace), which are consistent with tENTH existing as a monomer in solution.