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(a–d) Serum neutralizing antibody titers against scAAV2IL-1ra and scAAV6IL-1ra in high (a and b) and low (c and d) dosed animals. Levels of neutralizing antibodies to S2 are highest in the high dosed horses (a and b) and are low for most of the length of the study to S6. Levels of neutralizing antibodies to S2 are also high in the low dosed horses (c and d). Neutralizing antibodies to S6 rise following injection at Day 154 and stay elevated through the termination of the study.
