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. Author manuscript; available in PMC: 2017 Aug 23.
Published in final edited form as: Sci Transl Med. 2017 Jun 28;9(396):eaal3653. doi: 10.1126/scitranslmed.aal3653

Figure 4. Pharmacokinetics of GS-5734 in Ces1c−/− mice.

Figure 4

(A) Pharmacokinetics in Ces1c−/− mouse plasma following subcutaneous administration of 25mg/kg GS-5734. Longitudinal plasma samples were taken to measure prodrug GS-5734, intermediate metabolites Ala-Met, and nucleoside by LC/MS. (B) Lung triphosphate in Ces1c−/− mouse lung 4 hr following subcutaneous administration of 50mg/kg GS-5734. Nucleotide monophosphate (Nuc-MP), diphosphate (Nuc-DP), triphosphate (Nuc-TP) and total nucleotide (sum of Nuc-MP, DP and TP) is displayed. (C) Pharmacokinetics of total nucleotide in Ces1c−/− mouse lung following subcutaneous administration of GS-5734 at 25mg/kg twice daily (BID) or 50mg/kg once daily (QD).