Skip to main content

View full-text article in PMC

. Author manuscript; available in PMC: 2017 Nov 15.

Published in final edited form as: Cancer Res. 2016 Oct 3;76(22):6657–6668. doi: 10.1158/0008-5472.CAN-16-0568

Table 1. Combination index values.

CI values show synergy between lurbinectedin and irinotecan.

	Experimental Points			Median Effect Equation
	2X IC₅₀	IC₅₀	0.5X IC₅₀	ED₅₀	ED₇₅
Trabectedin & SN38	1.03 +/- 0.07	0.67 +/- 0.03	1.04 +/- 0.24	0.55 +/- 0.25	0.82 +/- 0.23
Lurbinectedin & SN38	0.93 +/- 0.10	0.63 +/- 0.03	1.10 +/- 0.24	0.67 +/- 0.09	0.81 +/- 0.09

CI < 1 = synergy; CI = 1 is additive, CI >1 = antagonism.