Table 1. Combination index values.
Experimental Points | Median Effect Equation | ||||
---|---|---|---|---|---|
2X IC50 | IC50 | 0.5X IC50 | ED50 | ED75 | |
Trabectedin & SN38 | 1.03 +/- 0.07 | 0.67 +/- 0.03 | 1.04 +/- 0.24 | 0.55 +/- 0.25 | 0.82 +/- 0.23 |
Lurbinectedin & SN38 | 0.93 +/- 0.10 | 0.63 +/- 0.03 | 1.10 +/- 0.24 | 0.67 +/- 0.09 | 0.81 +/- 0.09 |
CI < 1 = synergy; CI = 1 is additive, CI >1 = antagonism.