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. Author manuscript; available in PMC: 2018 May 11.
Published in final edited form as: J Med Chem. 2017 Apr 19;60(9):3958–3978. doi: 10.1021/acs.jmedchem.7b00259

Scheme 2.

Scheme 2

aReagents and conditions: (a) i. Phenols 23-26, 29, NaH, DMF, 0 °C, ii. 30 (in DMF), 0 °C; (b) i. K2CO3, MeOH, reflux, ii. HCI/MeOH, ether, r.t., or TFA/DCM (for 35), after isolation.