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. Author manuscript; available in PMC: 2018 May 11.
Published in final edited form as: J Med Chem. 2017 Apr 19;60(9):3958–3978. doi: 10.1021/acs.jmedchem.7b00259

Figure 4.

Figure 4

Active site structures of 9 bound to rat nNOS (A), human nNOS (B), and human eNOS (C). Note the alternate rotamer assumed by His342 as a result of a possible clash with the ethyl group in hnNOS (B).