Fig. 3.
GnRH antibody titer correlation with testosterone (a), total sperm count (b), and scrotal volume (c) in a representative cat following a single dose of the GnRH vaccine GonaCon™. The GnRH antibody titer reached a contraceptive level within one month of vaccination after which testosterone and sperm count decreased to undetectable levels and scrotal volume decreased. GnRH antibody titer waned 12 months after vaccination, which was associated with recovery of testosterone production, normal sperm counts, and increased scrotal volume.