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Summary of Screening Results
| spectrum library | 2320 compounds |
hit rate |
|---|---|---|
| initial AlphaScreen hits | 99 compounds | 4.26% |
| single point biotin-GST control counterscreenfilter | 41 compounds | 1.76% |
| favorable IC50’s and structures filter | 7 compounds | 0.30% |
| dose−response curves IC50’s PPI vs biotin-GSTfilter | 4 compounds | 0.17% |
| RGS17 specific differential scanning fluorimetry | 3 compounds | 0.13% |
