Table 1.
Comparison of clinical and demographic factors at baseline
| Responder (n = 24)
|
Non-responder (n = 11)
|
||||
|---|---|---|---|---|---|
| Variables | Mean (SD) | N (%) | Mean (SD) | N (%) | p-value |
| Age (years) | 67.2 (5.7) | 73.5 (9.3) | 0.05 | ||
| Sex (female) | 15 (68.6) | 4 (31.5) | 0.3 | ||
| Education (years) | 15.5 (1.9) | 14.3 (4.7) | 0.7 | ||
| Age of first episode (years) | 39.6 (21.72) | 41.4 (29.3) | 0.9 | ||
| Medical burden | |||||
| CIRS | 4.9 (3.7) | 5.5 (3.2) | 0.6 | ||
| CVRF | 11.0 (6.2) | 10.7 (4.6) | 0.7 | ||
| Mood | |||||
| HAM-D (screen) | 18.2 (2.3) | 20.3 (3.6) | 0.11 | ||
| HAM-D (16 weeks) | 4.5 (4.4) | 12.6 (3.9) | 0.0006 | ||
| MADRS (screen) | 17.0 (2.4) | 20.1 (4.0) | 0.07 | ||
| MADRS (16 weeks) | 5.5 (5.3) | 10.8 (4.2) | 0.008 | ||
| HAM-A* (screen) | 7.8 (2.3) | 11.2 (4.7) | 0.02 | ||
| HAM-A (16 weeks) | 2.7 (2.2) | 6.0 (3.3) | 0.01 | ||
| Cognition | |||||
| MMSE* | 28.8 (1.2) | 27.5 (1.6) | 0.02 | ||
| Drug doses (ng/ml) | |||||
| Citalopram | 35.00 (20.6) | 16.36 (23.3) | 0.06 | ||
| Methylphenidate | 14.38 (12.4) | 11.82 (9.5) | 0.55 | ||
| Drug levels (ng/ml) | |||||
| Citalopram | 91.01 (75.1) | 34.82 (53.9) | 0.08 | ||
| Dexmethylphenidate | 34.20 (34.3) | 13.38 (20.7) | 0.15 | ||
| Ritalin | 1.64 (2.3) | 0.56 (0.7) | 0.48 | ||
CIRS, Cumulative Illness Rating Scale; CVRF, Cerebrovascular Risk Factor Prediction Chart; HAM-D, Hamilton Depression Rating Scale; MADRS, Montgomery–Åsberg Depression Rating Scale; HAM-A, Hamilton Anxiety Rating Scale; MMSE, Mini-mental state examination.
*
Significance is reduced to p = 0.07 for HAM-A and p = 0.08 for MMSE, when controlling for age.